Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal transduction and targeted therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Histone deacetylase complexes: Structure, regulation and function

MD Asmamaw, A He, LR Zhang, HM Liu… - Biochimica et Biophysica …, 2024 - Elsevier
Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes
with deacetylase function are among the epigenetic corepressor complexes in the nucleus …

DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer

Y Zhang, R Kong, W Yang, K Hu, Z Zhao, L Li, X Geng… - Cancer Letters, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic tumor
microenvironment (TME), which aids tumor progression, drug resistance, and immune …

RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression

X Yu, P Zhao, Q Luo, X Wu, Y Wang, Y Nan, S Liu… - Oncogene, 2024 - nature.com
Dysregulated expression of long-stranded non-coding RNAs is strongly associated with
carcinogenesis. However, the precise mechanisms underlying their involvement in ovarian …

Graphene oxide nanoarchitectures in cancer therapy: Drug and gene delivery, phototherapy, immunotherapy, and vaccine development

MS Sadeghi, FH Sangrizeh, N Jahani, MS Abedin… - Environmental …, 2023 - Elsevier
The latest advancements in oncology involves the creation of multifunctional nanostructures.
The integration of nanoparticles into the realm of cancer therapy has brought about a …

Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect

PY Siak, WS Heng, SSH Teoh, YY Lwin… - Journal of Translational …, 2023 - Springer
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with high propensity for
lymphatic spread and distant metastasis. It is prominent as an endemic malignancy in …

Epigenetic regulation in cancer

M Gu, B Ren, Y Fang, J Ren, X Liu, X Wang… - MedComm, 2024 - Wiley Online Library
Epigenetic modifications are defined as heritable changes in gene activity that do not
involve changes in the underlying DNA sequence. The oncogenic process is driven by the …

Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer

CK Looi, LC Foong, FFL Chung, ASB Khoo… - Cell Biology and …, 2023 - Springer
Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer that is highly
associated with Epstein-Barr virus (EBV) infection. EBV acts as an epigenetic driver in NPC …

Stable knockdown of Drp1 improves retinoic acid-BDNF-induced neuronal differentiation through global transcriptomic changes and results in reduced …

M Ghani, P Zohar, G Ujlaki, M Tóth… - Frontiers in Cell and …, 2024 - frontiersin.org
Background: Dynamin-related protein Drp1—a major mitochondrial fission protein—is
widely distributed in the central nervous system and plays a crucial role in regulating …

A glimpse into novel acylations and their emerging role in regulating cancer metastasis

H Shi, W Cui, Y Qin, L Chen, T Yu, J Lv - Cellular and Molecular Life …, 2024 - Springer
Metastatic cancer is a major cause of cancer-related mortality; however, the complex
regulation process remains to be further elucidated. A large amount of preliminary …