Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome
that affects children and adults. Individuals with NF1 are at high risk for central nervous …

Idiopathic multicentric Castleman disease (iMCD) is a rare and poorly understood
hematologic disorder characterized by lymphadenopathy, systemic inflammation …

PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free
survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low …

Background IDH-mutant diffuse gliomas are heterogeneous, and improved methods for
optimal patient therapeutic stratification are needed. PI3K/AKT/mTOR signaling activity can …

The mammalian Target of Rapamycin (mTOR) is a molecular complex equipped with kinase
activity which controls cell viability being key in the PI3K/PTEN/Akt pathway. mTOR acts by …

Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma
(PA) component or piloid features, which may be associated with aggressive behavior, but …

Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR)
pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is …

Introduction Radiotherapy is one of the most common types of cancer treatment modalities.
Radiation can affect both cancer and normal tissues, which limits the whole delivered dose …

Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in young children.
While they are typically associated with good overall survival, children with these central …