O-GlcNAcylation and its role in the immune system
YH Chang, CL Weng, KI Lin - Journal of biomedical science, 2020 - Springer
Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …
The mechanism of V (D) J joining: lessons from molecular, immunological, and comparative analyses
SM Lewis - Advances in immunology, 1994 - Elsevier
Publisher Summary This chapter attempts an interdisciplinary perspective to consider that
that both molecular biologists and immunologists have learned about the V (D) J …
that both molecular biologists and immunologists have learned about the V (D) J …
Syk tyrosine kinase required for mouse viability and B-cell development
THE Syk cytoplasmic protein-tyrosine kinase has two amino-terminal SH2 domains and a
carboxy-terminal catalytic domain1. Syk, and its close relative ZAP-70 (ref. 2), are apparently …
carboxy-terminal catalytic domain1. Syk, and its close relative ZAP-70 (ref. 2), are apparently …
Positive selection of lymphocytes
H von Boehmer - Cell, 1994 - Elsevier
Simplistically, one may view the immune system as a war machine consisting of numerous
lymphocytes, each with a. specific surface receptor for antigen, designed to protect the …
lymphocytes, each with a. specific surface receptor for antigen, designed to protect the …
T-cell repertoire diversity and clonal expansions in normal and clinical samples
C Pannetier, J Even, P Kourilsky - Immunology today, 1995 - cell.com
Christophe Pannetier, Jos Even and Philippe Kourilsky lmproved polymerase chailr reaction
(RX)-based methods now permit a mare in-depth analysis of the repertoire of T cells …
(RX)-based methods now permit a mare in-depth analysis of the repertoire of T cells …
E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
G Bain, I Engel, ECR Maandag… - … and cellular biology, 1997 - Am Soc Microbiol
The E2A gene products, E12 and E47, are critical for proper early B-cell development and
commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte …
commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte …
Structure and function of the pre-T cell receptor
H von Boehmer, HJ Fehling - Annual review of immunology, 1997 - annualreviews.org
▪ Abstract The pre-T cell receptor (pre-TCR) that minimally consists of the TCRβ chain and
the disulfide-linked pre-T cell receptor alpha (pTα) chain in association with signal …
the disulfide-linked pre-T cell receptor alpha (pTα) chain in association with signal …
A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro
MS Carter, J Doskow, P Morris, S Li, RP Nhim… - Journal of Biological …, 1995 - ASBMB
Gene rearrangement during the ontogeny of T-and B-cells generates an enormous
repertoire of T-cell receptor (TCR) and immunoglobulin (Ig) genes. Because of the error …
repertoire of T-cell receptor (TCR) and immunoglobulin (Ig) genes. Because of the error …
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
E Fayard, G Xue, A Parcellier, L Bozulic… - … 3-kinase in Health and …, 2011 - Springer
Abstract Protein kinase B (PKB/Akt) is a serine/threonine protein kinase that created serious
interest when it was revealed as a mediator of the PI3K pathway. It comprises three isoforms …
interest when it was revealed as a mediator of the PI3K pathway. It comprises three isoforms …
T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice
The identification is made in normal mice of the stages in T cell development at which the
rearranged p chain of the T cell receptor (TCR) is utilized to promote T cell maturation …
rearranged p chain of the T cell receptor (TCR) is utilized to promote T cell maturation …