Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
The SWI/SNF complex in cancer—biology, biomarkers and therapy
P Mittal, CWM Roberts - Nature reviews Clinical oncology, 2020 - nature.com
Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …
[HTML][HTML] New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia
Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer
WG Kaelin - The Journal of Clinical Investigation, 2022 - jci.org
Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients …
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients …
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer
Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
R Hoefflin, S Harlander, S Schäfer, P Metzger… - Nature …, 2020 - nature.com
Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …
Chromatin remodellers as therapeutic targets
HA Malone, CWM Roberts - Nature Reviews Drug Discovery, 2024 - nature.com
Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis
Translocation renal cell carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3
fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we …
fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we …
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune
checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and …
checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and …