Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …

Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Cognitive decline is a hallmark of the aging nervous system, characterized by increasing
memory loss and a deterioration of mental capacity, which in turn creates a favorable context …

Aging is a major risk factor for many human diseases, including cognitive impairment, which
affects a large population of the elderly. In the past few decades, our understanding of the …

The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for Alzheimer's disease
(AD). Multiple regulatory elements, spanning the extended TOMM40-APOE-APOC2 region …

Parkinson disease (PD) is a common neurodegenerative disorder that progresses with age,
with an increasing number of symptoms. Some of the efforts to understand PD progression …

DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …

An important part of the central nervous system (CNS), the cerebellum is involved in motor
control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in …