Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently,
with coat proteins. Coat proteins are required for cargo selection and membrane …

The fusion of transport vesicles with their target membranes is fundamental for intracellular
membrane trafficking and diverse physiological processes and is driven by the assembly of …

The study of glycosylphosphatidylinositol-anchored-protein sorting has led to some
surprising new findings and concepts. Evidence is accumulating that, during their delivery to …

The exocyst is an octameric protein complex, which mediates the tethering of post-Golgi
secretory vesicles to the plasma membrane before exocytic fusion. The exocyst assembles …

Despite the recent progress in the field of membrane traffic, the question of how the
specificity of membrane fusion is achieved has yet to be resolved. It has become apparent …

A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer,
gastric cancer, and/or glioblastoma includes administering to said patient a composition …

Intracellular trafficking entails the budding, transport, tethering, and fusion of transport
vesicles and other membrane carriers. Here we review recent progress toward a …

The exocyst is an evolutionarily conserved octameric protein complex that mediates the
tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis and is …

▪ Abstract The SNARE superfamily has become, since its discovery approximately a decade
ago, the most intensively studied element of the protein machinery involved in intracellular …