Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Faecalibacterium: a bacterial genus with promising human health applications

R Martín, D Rios-Covian, E Huillet… - FEMS microbiology …, 2023 - academic.oup.com
In humans, many diseases are associated with alterations in gut microbiota, namely
increases or decreases in the abundance of specific bacterial groups. One example is the …

Microbiome diversity protects against pathogens by nutrient blocking

F Spragge, E Bakkeren, MT Jahn, E BN Araujo… - Science, 2023 - science.org
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

Machine learning for microbiologists

F Asnicar, AM Thomas, A Passerini… - Nature Reviews …, 2024 - nature.com
Abstract Machine learning is increasingly important in microbiology where it is used for tasks
such as predicting antibiotic resistance and associating human microbiome features with …

[HTML][HTML] Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

L Derosa, B Routy, AM Thomas, V Iebba, G Zalcman… - Nature medicine, 2022 - nature.com
Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …

Identification of antimicrobial peptides from the human gut microbiome using deep learning

Y Ma, Z Guo, B **a, Y Zhang, X Liu, Y Yu, N Tang… - Nature …, 2022 - nature.com
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights

B Srour, MC Kordahi, E Bonazzi… - The lancet …, 2022 - thelancet.com
Epidemiological studies have suggested a role for ultra-processed foods in numerous
chronic inflammatory diseases such as inflammatory bowel diseases and metabolic …

A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - journals.asm.org
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

The metabolic nature of inflammatory bowel diseases

TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …