[HTML][HTML] Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy

S Cheng, D Jiang, X Lan, K Liu, C Fan - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Abstract Voltage-gated potassium channel 1.3 (Kv1. 3) has emerged as a pivotal player in
numerous biological processes and pathological conditions, sparking considerable interest …

Voltage-gated potassium channel Kv1. 3 as a target in therapy of cancer

A Teisseyre, A Palko-Labuz, K Sroda-Pomianek… - Frontiers in …, 2019 - frontiersin.org
Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …

Voltage-gated potassium channels as regulators of cell death

M Bachmann, W Li, MJ Edwards, SA Ahmad… - Frontiers in cell and …, 2020 - frontiersin.org
Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

Single‐cell damage elicits regional, nematode‐restricting ethylene responses in roots

P Marhavý, A Kurenda, S Siddique… - The EMBO …, 2019 - embopress.org
Plants are exposed to cellular damage by mechanical stresses, herbivore feeding, or
invading microbes. Primary wound responses are communicated to neighboring and distal …

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

M Li, P Tian, Q Zhao, X Ma, Y Zhang - Frontiers in oncology, 2023 - frontiersin.org
In recent years, the role of potassium channels in tumors has been intensively studied.
Potassium channel proteins are widely involved in various physiological and pathological …

Proximity labeling proteomics reveals Kv1. 3 potassium channel immune interactors in microglia

CA Bowen, HM Nguyen, Y Lin, P Bagchi… - Molecular & Cellular …, 2024 - mcponline.org
Microglia are resident immune cells of the brain and regulate its inflammatory state. In
neurodegenerative diseases, microglia transition from a homeostatic state to a state referred …

The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation

R Immler, W Nadolni, A Bertsch, V Morikis… - Cardiovascular …, 2022 - academic.oup.com
Aims Neutrophil trafficking within the vasculature strongly relies on intracellular calcium
signalling. Sustained Ca2+ influx into the cell requires a compensatory efflux of potassium to …

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Š Gubič, LA Hendrickx, Ž Toplak… - Medicinal research …, 2021 - Wiley Online Library
Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …

Unique molecular characteristics and microglial origin of Kv1. 3 channel–positive brain myeloid cells in Alzheimer's disease

S Ramesha, S Rayaprolu, CA Bowen, CR Giver… - Proceedings of the …, 2021 - pnas.org
Kv1. 3 potassium channels, expressed by proinflammatory central nervous system
mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating …

[HTML][HTML] How the potassium channel response of T lymphocytes to the tumor microenvironment shapes antitumor immunity

M Chirra, HS Newton, VS Gawali, TM Wise-Draper… - Cancers, 2022 - mdpi.com
Simple Summary Ion channels are proteins that control the movement of ions across the
membranes of cells, thus regulating their physiological functions. In T lymphocytes, ion …