Background Despite evidence from twin and family studies for an important contribution of
genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly …

In the past decade, precision genomics based medicine has emerged to provide tailored
and effective healthcare for patients depending upon their genetic features. Genome Wide …

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying
individuals at low and high risk of develo** CRC, as they can then be offered targeted …

Polygenic scores (PGS) summarize the genetic contribution of a person's genotype to a
disease or phenotype. They can be used to group participants into different risk categories …

The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted …

Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …

Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility
of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk …

Gene discovery, estimation of heritability captured by SNP arrays, inference on genetic
architecture and prediction analyses of complex traits are usually performed using different …

Artificial Intelligence revolutionizes the drug development process that can quickly identify
potential biologically active compounds from millions of candidate within a short period. The …

Understanding the genetic architecture of gene expression traits is key to elucidating the
underlying mechanisms of complex traits. Here, for the first time, we perform a systematic …