Age-related macular degeneration (AMD), a progressive condition that is untreatable in up
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …

The retina is an immune privileged tissue, which is protected from external and internal
insults by its blood-retina barriers and immune suppressive microenvironment. Apart from …

Age related macular degeneration (AMD) is the leading cause of vision loss of those over
the age of 65 in the industrialized world. The prevalence and need to develop effective …

Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory
diseases, including age-related macular degeneration (AMD). AMD is the leading cause of …

Para-inflammation is a tissue adaptive response to noxious stress or malfunction and has
characteristics that are intermediate between basal and inflammatory states (Medzhitov …

The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is
unclear. Here we demonstrated that all retinal MCs express CX3C chemokine receptor 1 …

Reactive oxygen species (ROS) generated during inflammation are believed to play critical
roles in various ocular diseases. However, the underlying mechanisms remain poorly …

Oxidative damage and inflammation are related to the pathogenesis of age-related macular
degeneration (AMD). Epidemiologic studies suggest that insufficient dietary lutein and …

Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

To address the potential for an outer segment (OS) contribution to the sub-retinal pigment
epithelium (RPE) lesions of age-related maculopathy (ARM), we quantified esterified and …