Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID‐19

L Steardo, L Steardo Jr, R Zorec… - Acta Physiologica …, 2020 - pmc.ncbi.nlm.nih.gov
The new coronavirus, classified as severe acute respiratory syndrome (SARS)-CoV-2 that
emerged in Hubei province in China, causes a new coronavirus disease, which was termed …

The use of brain organoids to investigate neural development and disease

E Di Lullo, AR Kriegstein - Nature Reviews Neuroscience, 2017 - nature.com
Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …

Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection

M Watanabe, JE Buth, N Vishlaghi… - Cell reports, 2017 - cell.com
The human cerebral cortex possesses distinct structural and functional features that are not
found in the lower species traditionally used to model brain development and disease …

[HTML][HTML] Building models of brain disorders with three-dimensional organoids

ND Amin, SP Paşca - Neuron, 2018 - cell.com
Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …

Develo** human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology

R Xu, AJ Boreland, X Li, C Erickson, M **, C Atkins… - Stem cell reports, 2021 - cell.com
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in
animal models cannot accurately model human microglia due to notable transcriptomic and …

Zika virus structure, maturation, and receptors

D Sirohi, RJ Kuhn - The Journal of infectious diseases, 2017 - academic.oup.com
The emergence of Zika virus (ZIKV) as a major public health threat has focused research on
understanding virus biology and develo** a suite of strategies for disease intervention …

Virus–receptor interactions: the key to cellular invasion

MS Maginnis - Journal of molecular biology, 2018 - Elsevier
Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

C Zhu, Y Wei, X Wei - Molecular cancer, 2019 - Springer
Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a
member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 …

The human microglial HMC3 cell line: where do we stand? A systematic literature review

C Dello Russo, N Cappoli, I Coletta… - Journal of …, 2018 - Springer
Microglia, unique myeloid cells residing in the brain parenchyma, represent the first line of
immune defense within the central nervous system. In addition to their immune functions …