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Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID‐19
L Steardo, L Steardo Jr, R Zorec… - Acta Physiologica …, 2020 - pmc.ncbi.nlm.nih.gov
The new coronavirus, classified as severe acute respiratory syndrome (SARS)-CoV-2 that
emerged in Hubei province in China, causes a new coronavirus disease, which was termed …
emerged in Hubei province in China, causes a new coronavirus disease, which was termed …
The use of brain organoids to investigate neural development and disease
E Di Lullo, AR Kriegstein - Nature Reviews Neuroscience, 2017 - nature.com
Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …
neurobiology. Much of our current understanding of human brain development has been …
The emergence of Zika virus and its new clinical syndromes
TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …
threat because of its potential to generate explosive epidemics and ability to cause …
Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection
The human cerebral cortex possesses distinct structural and functional features that are not
found in the lower species traditionally used to model brain development and disease …
found in the lower species traditionally used to model brain development and disease …
[HTML][HTML] Building models of brain disorders with three-dimensional organoids
ND Amin, SP Paşca - Neuron, 2018 - cell.com
Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …
Develo** human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in
animal models cannot accurately model human microglia due to notable transcriptomic and …
animal models cannot accurately model human microglia due to notable transcriptomic and …
Zika virus structure, maturation, and receptors
The emergence of Zika virus (ZIKV) as a major public health threat has focused research on
understanding virus biology and develo** a suite of strategies for disease intervention …
understanding virus biology and develo** a suite of strategies for disease intervention …
Virus–receptor interactions: the key to cellular invasion
MS Maginnis - Journal of molecular biology, 2018 - Elsevier
Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …
AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications
C Zhu, Y Wei, X Wei - Molecular cancer, 2019 - Springer
Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a
member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 …
member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 …
The human microglial HMC3 cell line: where do we stand? A systematic literature review
C Dello Russo, N Cappoli, I Coletta… - Journal of …, 2018 - Springer
Microglia, unique myeloid cells residing in the brain parenchyma, represent the first line of
immune defense within the central nervous system. In addition to their immune functions …
immune defense within the central nervous system. In addition to their immune functions …