In Vitro Human Cell Line Models to Predict Clinical Response to Anticancer Drugs
N Niu, L Wang - Pharmacogenomics, 2015 - Taylor & Francis
In vitro human cell line models have been widely used for cancer pharmacogenomic studies
to predict clinical response, to help generate pharmacogenomic hypothesis for further …
to predict clinical response, to help generate pharmacogenomic hypothesis for further …
Significance, detection and markers of disseminated breast cancer cells
M Lacroix - Endocrine-related cancer, 2006 - erc.bioscientifica.com
The development of distant metastases is the major cause of death from breast cancer. In
order to predict and prevent tumour spreading, many attempts are being made to detect …
order to predict and prevent tumour spreading, many attempts are being made to detect …
A community effort to assess and improve drug sensitivity prediction algorithms
Predicting the best treatment strategy from genomic information is a core goal of precision
medicine. Here we focus on predicting drug response based on a cohort of genomic …
medicine. Here we focus on predicting drug response based on a cohort of genomic …
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set
High-throughput and high-content databases are increasingly important resources in
molecular medicine, systems biology, and pharmacology. However, the information usually …
molecular medicine, systems biology, and pharmacology. However, the information usually …
A multivariate approach to the integration of multi-omics datasets
Background To leverage the potential of multi-omics studies, exploratory data analysis
methods that provide systematic integration and comparison of multiple layers of omics …
methods that provide systematic integration and comparison of multiple layers of omics …
Global proteome analysis of the NCI-60 cell line panel
The NCI-60 cell line collection is a very widely used panel for the study of cellular
mechanisms of cancer in general and in vitro drug action in particular. It is a model system …
mechanisms of cancer in general and in vitro drug action in particular. It is a model system …
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents
G Zoppoli, M Regairaz, E Leo… - Proceedings of the …, 2012 - National Acad Sciences
DNA-damaging agents (DDAs) constitute the backbone of treatment for most human tumors.
Here we used the National Cancer Institute Antitumor Cell Line Panel (the NCI-60) to identify …
Here we used the National Cancer Institute Antitumor Cell Line Panel (the NCI-60) to identify …
Discovery of multi-dimensional modules by integrative analysis of cancer genomic data
Recent technology has made it possible to simultaneously perform multi-platform genomic
profiling (eg DNA methylation (DM) and gene expression (GE)) of biological samples …
profiling (eg DNA methylation (DM) and gene expression (GE)) of biological samples …
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
ON Ikediobi, H Davies, G Bignell, S Edkins… - Molecular cancer …, 2006 - AACR
The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer
Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been …
Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been …
CellMiner: a relational database and query tool for the NCI-60 cancer cell lines
Background Advances in the high-throughput omic technologies have made it possible to
profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional …
profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional …