Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …

Background Many existing bioinformatics predictors are based on machine learning
technology. When applying these predictors in practical studies, their predictive …

Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …

The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …

Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes,
genome-wide binding sites for proteins, and many other molecular processes. However …

Algorithms that accurately predict gene structure from primary sequence alone were
transformative for annotating the human genome. Can we also predict the expression levels …

Although the similarities between humans and mice are typically highlighted,
morphologically and genetically, there are many differences. To better understand these two …

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …

Background Although draft genomes are available for most agronomically important plant
species, the majority are incomplete, highly fragmented, and often riddled with assembly …

Histone modifications reflect gene activity, but the relationship between cause and
consequence of transcriptional control is heavily debated. Recent developments in rewriting …