Perspective review of what is needed for molecular-specific fluorescence-guided surgery

BW Pogue, EL Rosenthal, S Achilefu… - … of biomedical optics, 2018‏ - spiedigitallibrary.org
Molecular image-guided surgery has the potential for translating the tools of molecular
pathology to real-time guidance in surgery. As a whole, there are incredibly positive …

Optical innovations in surgery

E De Boer, NJ Harlaar, A Taruttis… - Journal of British …, 2015‏ - academic.oup.com
Background In the past decade, there has been a major drive towards clinical translation of
optical and, in particular, fluorescence imaging in surgery. In surgical oncology, radical …

NIR‐II fluorescence endoscopy for targeted imaging of colorectal cancer

Y Suo, F Wu, P Xu, H Shi, T Wang… - Advanced Healthcare …, 2019‏ - Wiley Online Library
Endoscopy is a clinical gold standard to exam the interior of a hollow organ or body cavity.
For the first of time, this study presents the design and construction of a fluorescent …

A roadmap for the clinical implementation of optical-imaging biomarkers

DJ Waterhouse, CRM Fitzpatrick, BW Pogue… - Nature biomedical …, 2019‏ - nature.com
Clinical workflows for the non-invasive detection and characterization of disease states
could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities …

Potential red-flag identification of colorectal adenomas with wide-field fluorescence molecular endoscopy

E Hartmans, JJJ Tjalma, MD Linssen… - …, 2018‏ - pmc.ncbi.nlm.nih.gov
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated
adenomas/polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch …

Molecular fluorescence endoscopy targeting vascular endothelial growth factor a for improved colorectal polyp detection

JJ Tjalma, PB Garcia-Allende… - Journal of Nuclear …, 2016‏ - jnm.snmjournals.org
Small and flat adenomas are known to carry a high miss-rate during standard white-light
endoscopy. Increased detection rate may be achieved by molecular fluorescence …

Near‐infrared light‐absorptive stealth liposomes for localized photothermal ablation of tumors combined with chemotherapy

M Li, C Teh, CY Ang, SY Tan, Z Luo… - Advanced Functional …, 2015‏ - Wiley Online Library
Although near‐infrared (NIR) light‐absorbing organic dyes have recently been proposed for
photothermal ablation of tumors, their clinical applications have often been hampered by …

Two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue

N Krstajić, AR Akram, TR Choudhary… - … of biomedical optics, 2016‏ - spiedigitallibrary.org
We demonstrate a fast two-color widefield fluorescence microendoscopy system capable of
simultaneously detecting several disease targets in intact human ex vivo lung tissue. We …

Detection of tumour-targeted IRDye800CW tracer with commercially available laparoscopic surgical systems

DJ Sikkenk, AJ Sterkenburg, I Schmidt, D Gorpas… - Diagnostics, 2023‏ - mdpi.com
(1) Introduction: Near-infrared fluorescence (NIRF) combined with tumour-targeted tracers,
such as bevacizumab-800CW, could aid surgical decision-making. This study explored the …

Research progress of autofluorescence imaging technology in the diagnosis of early gastrointestinal tumors

Y Bi, M Min, Y Cui, Y Xu, X Li - Cancer Control, 2021‏ - journals.sagepub.com
Early diagnosis and early treatment of gastrointestinal tumors are helpful to improve the
prognosis of patients. Endoscopy is the best method for the diagnosis of early …