Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila
melanogaster has proven to be a powerful model for the study of innate immunity. Early work …

Insect guts present distinctive environments for microbial colonization, and bacteria in the
gut potentially provide many beneficial services to their hosts. Insects display a wide range …

The gut microbiota significantly regulates the development and function of the innate and
adaptive immune system. The attribute of immunological memory has long been linked only …

Intestinal homeostasis is achieved, in part, by the integration of a complex set of
mechanisms that eliminate pathogens and tolerate the indigenous microbiota. Drosophila …

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that
underlie the complex relationships between a host and its microbiota. In addition to the …

Gut homeostasis is controlled by both immune and developmental mechanisms, and its
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …

All metazoan guts are subjected to immunologically unique conditions in which an efficient
antimicrobial system operates to eliminate pathogens while tolerating symbiotic commensal …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …

Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or
aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis …

Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic
stem cell activity. Somatic stem cells have to respond to tissue damage and proliferate …