Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most
frequently deregulated driver genes in human cancer. Because of its high prevalence of …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and hypovascular
tumor microenvironment. Nucleolar and spindle associated protein 1 (NUSAP1) is a …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

We characterized the epigenetic landscape of genes encoding long noncoding RNAs
(lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island …

Background Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several
epithelial cancers and is closely associated with poor prognosis. However, the role of …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Nucleotides are required for a wide variety of biological processes and are constantly
synthesized de novo in all cells. When cells proliferate, increased nucleotide synthesis is …