Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …

Amyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in
Alzheimer's disease (AD), the most common cause of dementia in the elderly. However, it …

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological
hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β …

Elevated levels of β-site APP cleaving enzyme 1 (BACE1) were found in the brain of some
sporadic Alzheimer's disease (AD) patients; however, the underlying mechanism is …

In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium
(Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase …

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …

Induction of TLR2 activation depends on its association with the adapter protein MyD88. We
have found that TLR2 and MyD88 levels are elevated in the hippocampus and cortex of …

Alzheimer's disease (AD) is characterized by the extracellular deposition of β-amyloid
peptide (Aβ) in cerebral plaques. Aβ is derived from the β-amyloid precursor protein (APP) …

Alzheimer's disease (AD) is one of most devastating diseases affecting elderly people.
Amyloid-β (Aβ) accumulation and the downstream pathological events such as oxidative …