Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important
regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF …

Highlights•bHLH-PAS proteins Met and Tai form a JH receptor that mediates JH function in
vivo.•The Met–Tai receptor complex is a JH-activated transcription factor.•JH activates Met …

Since it was first postulated by Wigglesworth in 1934, juvenile hormone (JH) is considered a
status quo hormone in insects because it prevents metamorphosis that is initiated by the …

Sex differentiation and hormones are essential for the development of sexual signals in
animals, and the regulation of sexual signals involves complex gene networks. However, it …

Insects comprise over half of the described species, and the acquisition of metamorphosis
must have contributed to their diversity and prosperity. The order Odonata (dragonflies and …

In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of
miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise …

Dengue has become a huge global health burden. It is currently recognized as the most
rapidly spreading mosquito-borne viral disease. Yet, there are currently no licensed …

Insect metamorphosis is regulated by two main hormones: ecdysone (20E), which promotes
molting, and juvenile hormone (JH), which inhibits adult morphogenesis. The transduction …

Juvenile hormone (JH) prevents metamorphosis during insect larval stages and promotes
adult reproductive processes. Krüppel-homolog 1 (Kr-h1), a zinc finger transcription factor …

Recent studies in vitro have reported that the Methoprene-tolerant (Met) and Taiman (Tai)
complex is the functional receptor of juvenile hormone (JH). Experiments in vivo of Met …