Flow cytometry allows quantitative analysis of the identity and effector function of individual
cells. However, it cannot provide information on cellular responses that occur within …

Recent developments in proteomics technology offer new opportunities for clinical
applications in hospital or specialized laboratories including the identification of novel …

Computational approaches of multicellular assemblies have reached a stage where they
may contribute to unveil the processes that underlie the organization of tissues and …

The burgeoning fields of in vivo three-dimensional (3D) microscopy and endomicroscopy, as
well as ex vivo tissue cytometry have introduced new challenges for tissue preparation and …

The composition of atherosclerotic (AS) plaques is crucial concerning rupture, thrombosis
and clinical events. Two plaque types are distinguished: stable and vulnerable plaques …

Understanding biological systems at the level of their relational (emergent) molecular
properties in functional protein networks relies on imaging methods, able to spatially resolve …

To understand how oncogenes affect genome organization, it is essential to visualize
fundamental processes such as DNA replication and transcription at high resolution in intact …

Functional super-resolution (fSR) microscopy is based on the automated toponome imaging
system (TIS). fSR-TIS provides insight into the myriad of different cellular functionalities by …

Background: Polychromatic analysis of biological specimens has become increasingly
important because of the emerging new fields of high‐content and high‐throughput single …

Hardware automation and software development have allowed a dramatic increase of
throughput in both acquisition and analysis of images by associating an optimized statistical …