Programmed DNA elimination in the parasitic nematode Ascaris

B Estrem, J Wang - PLoS pathogens, 2023 - journals.plos.org
In most organisms, the whole genome is maintained throughout the life span. However,
exceptions occur in some species where the genome is reduced during development …

[HTML][HTML] The global prevalence of Trichuris trichiura infection in humans (2010-2023): A systematic review and meta-analysis

H Behniafar, M Sepidarkish, MJ Tadi… - Journal of Infection and …, 2024 - Elsevier
This systematic review and meta-analysis study aimed to evaluate global Trichuris infection
prevalence, assessing progress towards the WHO's 2030 target. We searched international …

Worldwide absence of canonical benzimidazole resistance-associated mutations within β-tubulin genes from Ascaris

BP Jones, K Kozel, AJI Alonte, KKR Llanes, A Juhász… - Parasites & vectors, 2024 - Springer
Abstract Background The giant roundworm Ascaris is an intestinal nematode, causing
ascariasis by infecting humans and pigs worldwide. Recent estimates suggest that Ascaris …

Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection

LE Elizalde-Velázquez, J Schlosser-Brandenburg… - Scientific Reports, 2024 - nature.com
Helminth infections lead to an overdispersion of the parasites in humans as well as in
animals. We asked whether early immune responses against migrating Ascaris larvae are …

[HTML][HTML] Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity

HT Shanley, AC Taki, N Nguyen, T Wang… - International Journal for …, 2024 - Elsevier
Within the context of our anthelmintic discovery program, we recently identified and
evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal …

Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids

AJ Wolstenholme, EC Andersen… - Advances in …, 2024 - pmc.ncbi.nlm.nih.gov
The ascarids are a large group of parasitic nematodes that infect a wide range of animal
species. In humans, they cause neglected diseases of poverty; many animal parasites also …

An update on the current and emerging pharmacotherapy for the treatment of human ascariasis

KL Hon, AKC Leung - Expert opinion on pharmacotherapy, 2024 - Taylor & Francis
ABSTRACT Introduction Globally, Ascaris lumbricoides is the commonest helminthic
infection that affects people in underdeveloped countries and returning immigrants in …

[HTML][HTML] DNA prevalence of eukaryotic parasites with zoonotic potential in urban-associated birds

X Cabodevilla, JE Malo, D Aguirre de Carcer, J Zurdo… - Birds, 2024 - mdpi.com
Simple Summary Zoonoses are a growing threat to human health. Therefore, their
surveillance is especially important in densely populated areas such as cities. Modern cities …

Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings

RM Mugo, S Rausch, ZD Musimbi… - PLoS neglected …, 2024 - journals.plos.org
Background The standard diagnosis of Ascaris lumbricoides and other soil-transmitted
helminth (STH) infections relies on the detection of worm eggs by copromicroscopy …

Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte …

N Acevedo, A Lozano, J Zakzuk… - Frontiers in …, 2024 - frontiersin.org
Background Ascaris lumbricoides cystatin (Al-CPI) prevents the development of allergic
airway inflammation and dextran-induced colitis in mice models. It has been suggested that …