Practical recommendations for using ctDNA in clinical decision making
SA Cohen, MC Liu, A Aleshin - Nature, 2023 - nature.com
The continuous improvement in cancer care over the past decade has led to a gradual
decrease in cancer-related deaths. This is largely attributed to improved treatment and …
decrease in cancer-related deaths. This is largely attributed to improved treatment and …
Circulating tumor DNA and minimal residual disease (MRD) in solid tumors: current horizons and future perspectives
Y Peng, W Mei, K Ma, C Zeng - Frontiers in oncology, 2021 - frontiersin.org
Circulating tumor DNA (ctDNA) is cell-free DNA (cfDNA) fragment in the bloodstream that
originates from malignant tumors or circulating tumor cells. Recently, ctDNA has emerged as …
originates from malignant tumors or circulating tumor cells. Recently, ctDNA has emerged as …
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity
Detecting mutations from single DNA molecules is crucial in many fields but challenging.
Next-generation sequencing (NGS) affords tremendous throughput but cannot directly …
Next-generation sequencing (NGS) affords tremendous throughput but cannot directly …
[HTML][HTML] Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with …
NC Turner, C Swift, B Jenkins, L Kilburn, M Coakley… - Annals of …, 2023 - Elsevier
Background Post-treatment detection of circulating tumour DNA (ctDNA) in early-stage triple-
negative breast cancer (TNBC) patients predicts high risk of relapse. c-TRAK TN assessed …
negative breast cancer (TNBC) patients predicts high risk of relapse. c-TRAK TN assessed …
Liquid biopsy: from concept to clinical application
C Alix-Panabières, D Marchetti, JE Lang - Scientific Reports, 2023 - nature.com
The diagnosis and treatment of cancer presents a physical and mental burden to the patient,
often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with …
often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with …
A clinician's handbook for using ctDNA throughout the patient journey
SO Hasenleithner, MR Speicher - Molecular cancer, 2022 - Springer
Background The promise of precision cancer medicine presently centers around the
genomic sequence of a patient's tumor being translated into timely, actionable information to …
genomic sequence of a patient's tumor being translated into timely, actionable information to …
Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance
R Casolino, PA Beer, D Chakravarty… - CA: a cancer journal …, 2024 - Wiley Online Library
The last decade has seen rapid progress in the use of genomic tests, including gene panels,
whole‐exome sequencing, and whole‐genome sequencing, in research and clinical cancer …
whole‐exome sequencing, and whole‐genome sequencing, in research and clinical cancer …
Understanding and overcoming tumor heterogeneity in metastatic breast cancer treatment
N Pasha, NC Turner - Nature cancer, 2021 - nature.com
Rational development of targeted therapies has revolutionized metastatic breast cancer
outcomes, although resistance to treatment remains a major challenge. Advances in …
outcomes, although resistance to treatment remains a major challenge. Advances in …
Triple-negative breast cancer: promising prognostic biomarkers currently in development
J Sukumar, K Gast, D Quiroga, M Lustberg… - Expert review of …, 2021 - Taylor & Francis
Introduction: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer
associated with poor prognosis and limited treatment options. Validated prognostic and …
associated with poor prognosis and limited treatment options. Validated prognostic and …
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth
G Gydush, E Nguyen, JH Bae, T Blewett… - Nature Biomedical …, 2022 - nature.com
Assaying for large numbers of low-frequency mutations requires sequencing at extremely
high depth and accuracy. Increasing sequencing depth aids the detection of low-frequency …
high depth and accuracy. Increasing sequencing depth aids the detection of low-frequency …