Mesenchymal stem cell-derived exosomes: applications in regenerative medicine
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …
are then released into the extracellular space through a merging of the multivesicular body …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair
Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …
procedures are normally invasive and difficult to perform. Here, we develop and test a …
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
Angiogenesis after acute myocardial infarction
X Wu, MR Reboll, M Korf-Klingebiel… - Cardiovascular …, 2021 - academic.oup.com
Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …
A metal-organic framework-based immunomodulatory nanoplatform for anti-atherosclerosis treatment
Z Xu, Z Wu, S Huang, K Ye, Y Jiang, J Liu, J Liu… - Journal of Controlled …, 2023 - Elsevier
Immunomodulatory therapy has become a promising method for the clinical treatment of
many diseases. Recently, pilot studies revealed that immunomodulatory therapy exhibited …
many diseases. Recently, pilot studies revealed that immunomodulatory therapy exhibited …
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
Immune cells and immunotherapy for cardiac injury and repair
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …
significant advances, a full understanding of why the heart fails to fully recover function after …
Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies
Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …