Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
The microtubule-associated protein tau is integral to the pathogenesis of Alzheimer's
disease (AD), as well as several related disorders, termed tauopathies, in which tau is …
disease (AD), as well as several related disorders, termed tauopathies, in which tau is …
[HTML][HTML] Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas
Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …
Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases
Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases
(AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by …
(AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by …
Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease
Aggregation of microtubule-associated protein tau into insoluble intracellular neurofibrillary
tangles is a characteristic hallmark of Alzheimer's disease (AD) and other …
tangles is a characteristic hallmark of Alzheimer's disease (AD) and other …
[HTML][HTML] Retinal ganglion cell axonal compression by retinal vessels in light-induced retinal degeneration
Purpose To analyze the damage produced by light in mydriatic and miotic albino retinas
under two different sources of light. Methods Albino Sprague Dawley female rats were …
under two different sources of light. Methods Albino Sprague Dawley female rats were …
[HTML][HTML] Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study
We examined qualitatively and quantitatively in adult rat retinas the temporal degeneration
of the nerve fibre layer after intra-orbital optic nerve transection (IONT) or crush (IONC) …
of the nerve fibre layer after intra-orbital optic nerve transection (IONT) or crush (IONC) …
Charcot–Marie–Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments
A Holmgren, D Bouhy, V De Winter, B Asselbergh… - Acta …, 2013 - Springer
Mutations in the small heat shock protein HSPB1 (HSP27) are a cause of axonal Charcot–
Marie–Tooth neuropathy (CMT2F) and distal hereditary motor neuropathy. To better …
Marie–Tooth neuropathy (CMT2F) and distal hereditary motor neuropathy. To better …
Loss of prion protein leads to age-dependent behavioral abnormalities and changes in cytoskeletal protein expression
M Schmitz, C Greis, P Ottis, CJ Silva… - Molecular …, 2014 - Springer
The cellular prion protein (PrPC) is a highly conserved protein whose exact physiological
role remains elusive. In the present study, we investigated age-dependent behavioral …
role remains elusive. In the present study, we investigated age-dependent behavioral …
PKIS: computational identification of protein kinases for experimentally discovered protein phosphorylation sites
Background Dynamic protein phosphorylation is an essential regulatory mechanism in
various organisms. In this capacity, it is involved in a multitude of signal transduction …
various organisms. In this capacity, it is involved in a multitude of signal transduction …
Neurofilament phosphorylation and their proline‐directed kinases in health and disease
A Holmgren, D Bouhy… - Journal of the Peripheral …, 2012 - Wiley Online Library
The intermediate filaments called neurofilaments (NFs) are the main cytoskeleton elements
in neurons. They are mainly present in the adult axonal cytoskeleton, where they are …
in neurons. They are mainly present in the adult axonal cytoskeleton, where they are …