The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

In the three decades since pluripotent mouse embryonic stem (ES) cells were first described,
they have been derived and maintained by using various empirical combinations of feeder …

Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …

Naïve and primed pluripotent states retain distinct molecular properties, yet limited
knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N …

The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …