Delineating crosstalk mechanisms of the ubiquitin proteasome system that regulate apoptosis

I Gupta, K Singh, NK Varshney, S Khan - Frontiers in cell and …, 2018 - frontiersin.org
Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …

[HTML][HTML] Binding to the other side: The AT-Hook DNA-binding domain allows nuclear factors to exploit the DNA minor groove

S Battista, M Fedele, L Secco, AMD Ingo… - International Journal of …, 2024 - mdpi.com
The “AT-hook” is a peculiar DNA-binding domain that interacts with DNA in the minor groove
in correspondence to AT-rich sequences. This domain has been first described in the HMGA …

Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors

S Patel, K Ganbold, CH Cho, J Siddiqui, R Yildiz… - Nature …, 2024 - nature.com
White adipose tissue (WAT) is essential for lipid storage and systemic energy homeostasis.
Understanding adipocyte formation and stability is key to develo** therapies for obesity …

PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

KT Alhalabi, D Stichel, P Sievers, H Peterziel… - Acta …, 2021 - Springer
Large-scale molecular profiling studies in recent years have shown that central nervous
system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct …

Pooled‐matrix protein interaction screens using Barcode Fusion Genetics

N Yachie, E Petsalaki, JC Mellor, J Weile… - Molecular systems …, 2016 - embopress.org
High‐throughput binary protein interaction map** is continuing to extend our
understanding of cellular function and disease mechanisms. However, we remain one or …

[HTML][HTML] Bioinformatics analysis of the serine and glycine pathway in cancer cells

A Antonov, M Agostini, M Morello, M Minieri, G Melino… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Serine and glycine are amino acids that provide the essential precursors for the synthesis of
proteins, nucleic acids and lipids. Employing 3 subsequent enzymes, phosphoglycerate …

PATZ1 in non-small cell lung cancer: a new biomarker that negatively correlates with PD-L1 expression and suppresses the malignant phenotype

S Lucà, R Franco, A Napolitano, V Soria, A Ronchi… - Cancers, 2023 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer death worldwide. Most lung
cancers are classified as non-small cell lung cancer (NSCLC), which is diagnosed at an …

Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs

Y Li, M Tan, A Akkari-Henić, L Zhang, M Kip… - Nature Biomedical …, 2024 - nature.com
The functions of non-coding regulatory elements (NCREs), which constitute a major fraction
of the human genome, have not been systematically studied. Here we report a method …

[HTML][HTML] Transforming properties of Felis catus papillomavirus type 2 E6 and E7 putative oncogenes in vitro and their transcriptional activity in feline squamous cell …

G Altamura, A Corteggio, L Pacini, A Conte… - Virology, 2016 - Elsevier
Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell
carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study …

Dimerization choice and alternative functions of ZBTB transcription factors

S Barakat, E Ezen, İ Devecioğlu, M Gezen… - The FEBS …, 2024 - Wiley Online Library
Zinc Finger DNA‐binding domain‐containing proteins are the most populous family among
eukaryotic transcription factors. Among these, members of the BTB domain‐containing ZBTB …