Delineating crosstalk mechanisms of the ubiquitin proteasome system that regulate apoptosis
I Gupta, K Singh, NK Varshney, S Khan - Frontiers in cell and …, 2018 - frontiersin.org
Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …
[HTML][HTML] Binding to the other side: The AT-Hook DNA-binding domain allows nuclear factors to exploit the DNA minor groove
The “AT-hook” is a peculiar DNA-binding domain that interacts with DNA in the minor groove
in correspondence to AT-rich sequences. This domain has been first described in the HMGA …
in correspondence to AT-rich sequences. This domain has been first described in the HMGA …
Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors
S Patel, K Ganbold, CH Cho, J Siddiqui, R Yildiz… - Nature …, 2024 - nature.com
White adipose tissue (WAT) is essential for lipid storage and systemic energy homeostasis.
Understanding adipocyte formation and stability is key to develo** therapies for obesity …
Understanding adipocyte formation and stability is key to develo** therapies for obesity …
PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
KT Alhalabi, D Stichel, P Sievers, H Peterziel… - Acta …, 2021 - Springer
Large-scale molecular profiling studies in recent years have shown that central nervous
system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct …
system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct …
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics
High‐throughput binary protein interaction map** is continuing to extend our
understanding of cellular function and disease mechanisms. However, we remain one or …
understanding of cellular function and disease mechanisms. However, we remain one or …
[HTML][HTML] Bioinformatics analysis of the serine and glycine pathway in cancer cells
Serine and glycine are amino acids that provide the essential precursors for the synthesis of
proteins, nucleic acids and lipids. Employing 3 subsequent enzymes, phosphoglycerate …
proteins, nucleic acids and lipids. Employing 3 subsequent enzymes, phosphoglycerate …
PATZ1 in non-small cell lung cancer: a new biomarker that negatively correlates with PD-L1 expression and suppresses the malignant phenotype
Simple Summary Lung cancer is the leading cause of cancer death worldwide. Most lung
cancers are classified as non-small cell lung cancer (NSCLC), which is diagnosed at an …
cancers are classified as non-small cell lung cancer (NSCLC), which is diagnosed at an …
Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs
Y Li, M Tan, A Akkari-Henić, L Zhang, M Kip… - Nature Biomedical …, 2024 - nature.com
The functions of non-coding regulatory elements (NCREs), which constitute a major fraction
of the human genome, have not been systematically studied. Here we report a method …
of the human genome, have not been systematically studied. Here we report a method …
[HTML][HTML] Transforming properties of Felis catus papillomavirus type 2 E6 and E7 putative oncogenes in vitro and their transcriptional activity in feline squamous cell …
G Altamura, A Corteggio, L Pacini, A Conte… - Virology, 2016 - Elsevier
Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell
carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study …
carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study …
Dimerization choice and alternative functions of ZBTB transcription factors
S Barakat, E Ezen, İ Devecioğlu, M Gezen… - The FEBS …, 2024 - Wiley Online Library
Zinc Finger DNA‐binding domain‐containing proteins are the most populous family among
eukaryotic transcription factors. Among these, members of the BTB domain‐containing ZBTB …
eukaryotic transcription factors. Among these, members of the BTB domain‐containing ZBTB …