The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

PIEZO channels respond to piconewton-scale forces to mediate critical physiological and
pathophysiological processes,,,–. Detergent-solubilized PIEZO channels form bowl-shaped …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Mechanical load of the skeleton system is essential for the development, growth, and
maintenance of bone. However, the molecular mechanism by which mechanical stimuli are …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …

PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals.
Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms …

PIEZO2 is a mechanosensitive cation channel that has a key role in sensing touch, tactile
pain, breathing and blood pressure. Here we describe the cryo-electron microscopy …

Alteration of tissue mechanical properties is a physical hallmark of solid tumors including
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …