Topography, among other physical factors such as substrate stiffness and extracellular
forces, is known to have a great influence on cell behaviours. Optimization of topographical …

Unlike other tissue types, like epithelial tissue, which consist of cells with a much more
homogeneous structure and function, the nervous tissue spans in a complex multilayer …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

The surface topographies of artificial implants including surface roughness, surface groove
size and orientation, and surface pore size and distribution have a great influence on the …

Designing chiral materials to manipulate the biological activities of cells has been an
important area not only in chemistry and material science, but also in cell biology and …

Nerve growth strongly relies on multiple chemical and physical signals throughout
development and regeneration. Currently, a cure for injured neuronal tissue is an unmet …

The biomechanical properties of the brain microenvironment, which is composed of different
neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain …

Chirality is an intriguing and fundamental property of natural matter, which is especially
crucial in supporting the processes of living systems. The selective interactions between …

We report a simple method based upon coaxial electrospinning for the fabrication of aligned
microfibers engraved with nanoscale grooves to promote neurite outgrowth and cell …

Seamless neural interfaces conjoining neurons and electrochemical devices hold great
potential for highly efficient signal transmission across neural systems and the external …