Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023‏ - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Cerebral small vessel disease

Q Li, Y Yang, C Reis, T Tao, W Li, X Li… - Cell …, 2018‏ - journals.sagepub.com
Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small
arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological …

Prevalence of white matter hyperintensities increases with age

FJ Zhuang, Y Chen, WB He, ZY Cai - Neural regeneration …, 2018‏ - journals.lww.com
White matter hyperintensities (WMHs) that arise with age and/or atherosclerosis constitute a
heterogeneous disorder in the white matter of the brain. However, the relationship between …

Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study

H Jokinen, J Lipsanen, R Schmidt, F Fazekas… - Neurology, 2012‏ - neurology.org
Objective: To examine the independent contributions and combined interactions of medial
temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion …

Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities

BS Aribisala, Z Morris, E Eadie, A Thomas, A Gow… - …, 2014‏ - ahajournals.org
White matter hyperintensities (WMH) are associated with hypertension. We examined
interactions among blood pressure (BP), internal carotid artery (ICA) flow velocity …

Risk factors for incident dementia after stroke and transient ischemic attack

J Yang, A Wong, Z Wang, W Liu, L Au, Y **ong… - Alzheimer's & …, 2015‏ - Elsevier
Background We hypothesized that chronic brain changes are important substrates for
incident dementia after stroke and transient ischemic attack (TIA). Methods We compared …

Neurovascular alterations in vascular dementia: emphasis on risk factors

S Lecordier, D Manrique-Castano… - Frontiers in aging …, 2021‏ - frontiersin.org
Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Dementia in patients hospitalized with stroke: rates, time course, and clinico-pathologic factors

ST Pendlebury - International journal of stroke, 2012‏ - journals.sagepub.com
Stroke is a risk factor for dementia and dementia predisposes to stroke. Dementia
prevalence in subjects with stroke is comparable with that seen in stroke-free subjects who …

Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease

SM Heringa, YD Reijmer, A Leemans… - Journal of …, 2013‏ - journals.sagepub.com
Background: Cerebral microbleeds are a manifestation of small vessel disease and are
common in patients with Alzheimer's disease (AD). However, their clinical significance in this …

Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936

BS Aribisala, MC Valdés Hernández, NA Royle… - European …, 2013‏ - Springer
Objective Cerebral atrophy and white matter lesions (WMLs) are common in older people
with common risk factors, but it is unclear if they are related. We investigated whether and to …