Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Although nearly all mammalian species are diploid, whole-genome duplications occur in
select mammalian tissues as part of normal development. Such programmed …

Many cancer cells display a CIN (C hromosome In stability) phenotype, by which they exhibit
high rates of chromosome loss or gain at each cell cycle. Over the years, a number of …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

Centrioles are microtubule-derived structures that are essential for the formation of
centrosomes, cilia and flagella. The centrosome is the major microtubule organiser in animal …

Central to tumor evolution is the generation of genetic diversity. However, the extent and
patterns by which de novo karyotype alterations emerge and propagate within human …

Dividing cells almost always adopt a spherical shape. This is true of most eukaryotic cells
lacking a rigid cell wall and is observed in tissue culture and single-celled organisms, as …

The centrosome linker joins the two interphase centrosomes of a cell into one microtubule
organizing center. Despite increasing knowledge on linker components, linker diversity in …

Aneuploidy and chromosomal instability frequently co-exist, and aneuploidy is recognized
as a direct outcome of chromosomal instability. However, chromosomal instability is widely …

Centrosome aberrations are hallmarks of human cancers and contribute to the senescence
process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular …