Integrating organoids and organ-on-a-chip devices
Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
A comprehensive review on 3D tissue models: biofabrication technologies and preclinical applications
R **e, V Pal, Y Yu, X Lu, M Gao, S Liang, M Huang… - Biomaterials, 2024 - Elsevier
The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
[HTML][HTML] Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
The first microfluidic microphysiological systems (MPS) entered the academic scene more
than 15 years ago and were considered an enabling technology to human in vitro (patho) …
than 15 years ago and were considered an enabling technology to human in vitro (patho) …
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily
on the responses of the neurovascular unit. Here, we report the development and …
on the responses of the neurovascular unit. Here, we report the development and …
Development of a human primary gut-on-a-chip to model inflammatory processes
C Beaurivage, A Kanapeckaite, C Loomans… - Scientific reports, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex multi-factorial disease for which
physiologically relevant in vitro models are lacking. Existing models are often a compromise …
physiologically relevant in vitro models are lacking. Existing models are often a compromise …
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier
In this work we model the glomerular filtration barrier, the structure responsible for filtering
the blood and preventing the loss of proteins, using human podocytes and glomerular …
the blood and preventing the loss of proteins, using human podocytes and glomerular …
Recent advances in nanotechnology-based drug delivery systems for the kidney
The application of nanotechnology in medicine has the potential to make a great impact on
human health, ranging from prevention to diagnosis and treatment of disease. The kidneys …
human health, ranging from prevention to diagnosis and treatment of disease. The kidneys …
Mechanical stimulation: a crucial element of organ-on-chip models
CL Thompson, S Fu, HK Heywood… - … in bioengineering and …, 2020 - frontiersin.org
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
Human organoids for predictive toxicology research and drug development
T Matsui, T Shinozawa - Frontiers in Genetics, 2021 - frontiersin.org
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …
adult tissue stem cells via a process of self-organization that results in the formation of organ …
Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …