There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multi‐factorial, the cartilage …

The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

Host modulation therapy refers to a treatment concept in which drug therapies are used as
an adjunct to conventional periodontal treatment to ameliorate destructive aspects of the …

Joint tissues are exquisitely sensitive to their mechanical environment, and mechanical
loading may be the most important external factor regulating the development and long‐term …

The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes
were originally described as cleaving extracellular matrix (ECM) substrates with a …

Atherosclerosis, which is the most common chronic disease of the coronary artery,
constitutes a vascular pathology induced by inflammation and plaque accumulation within …

Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease.
Histone deacetylase inhibitors (HDACi), a new class of anti‐cancer agents, have recently …