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Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
Specialized pro-resolving mediator network: an update on production and actions
Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …
Formation, signaling and occurrence of specialized pro-resolving lipid mediators—what is the evidence so far?
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources
JL Harwood - International Journal of Molecular Sciences, 2023 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma
and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the …
and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the …
[HTML][HTML] Oxylipin profiling for clinical research: Current status and future perspectives
Oxylipins are potent lipid mediators with increasing interest in clinical research. They are
usually measured in systemic circulation and can provide a wealth of information regarding …
usually measured in systemic circulation and can provide a wealth of information regarding …
Regulation and functions of 15-lipoxygenases in human macrophages
Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …
Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites
The bloom and bust patterns of microalgae in aquatic systems contribute massively to global
biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation …
biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation …
[HTML][HTML] Formation of lipoxins and resolvins in human leukocytes
Specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins are formed by
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …
Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology
As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …