Inflammation in traumatic brain injury

TT Postolache, A Wadhawan, A Can… - Journal of …, 2020 - journals.sagepub.com
There is an increasing evidence that inflammation contributes to clinical and functional
outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing …

The closed-head impact model of engineered rotational acceleration (CHIMERA) as an application for traumatic brain injury pre-clinical research: a status report

EH McNamara, AA Grillakis, LB Tucker… - Experimental neurology, 2020 - Elsevier
Closed-head traumatic brain injury (TBI) is a worldwide concern with increasing prevalence
and cost to society. Rotational acceleration is a primary mechanism in TBI that results from …

Repeated mild head injury leads to wide-ranging deficits in higher-order cognitive functions associated with the prefrontal cortex

A Nolan, E Hennessy, K Krukowski… - Journal of …, 2018 - liebertpub.com
Traumatic brain injury (TBI) has long been identified as a precipitating risk factor for higher-
order cognitive deficits associated with the frontal and prefrontal cortices (PFC). In addition …

Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal …

SF Enam, SR Kader, N Bodkin, JG Lyon… - Journal of …, 2020 - Springer
Background Appropriately modulating inflammation after traumatic brain injury (TBI) may
prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of …

Acute blood levels of neurofilament light indicate one-year white matter pathology and functional impairment in repetitive mild traumatic brain injured mice

F Moro, I Lisi, D Tolomeo, G Vegliante… - Journal of …, 2023 - liebertpub.com
Mild traumatic brain injury (mTBI) mostly causes transient symptoms, but repeated (r) mTBI
can lead to neurodegenerative processes. Diagnostic tools to evaluate the presence of …

Diffusion tensor imaging of the evolving response to mild traumatic brain injury in rats

WS Hoogenboom, TG Rubin, K Ye… - Journal of …, 2019 - journals.sagepub.com
Mild traumatic brain injury (mTBI), also known as concussion, is a serious public health
challenge. Although most patients recover, a substantial minority suffers chronic disability …

Altered tau kinase activity in rTg4510 mice after a single interfaced CHIMERA traumatic brain injury

WH Cheng, H Cheung, A Kang, J Fan… - International Journal of …, 2023 - mdpi.com
Traumatic brain injury (TBI) is an established risk factor for neurodegenerative diseases. In
this study, we used the Closed Head Injury Model of Engineered Rotational Acceleration …

Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses

T Clément, JB Lee, A Ichkova, B Rodriguez‐Grande… - Glia, 2020 - Wiley Online Library
Mild‐traumatic brain injury (mTBI) represents~ 80% of all emergency room visits and
increases the probability of develo** long‐term cognitive disorders in children. To date …

PRMT7 can prevent neurovascular uncoupling, blood-brain barrier permeability, and mitochondrial dysfunction in repetitive and mild traumatic brain injury

CH Acosta, GA Clemons, CT Citadin, WC Carr… - Experimental …, 2023 - Elsevier
Mild traumatic brain injury (TBI) comprises the largest percentage of TBI-related injuries, with
pathophysiological and functional deficits that persist in a subset of TBI patients. In our three …