Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver …

LA Videla, MC Hernandez-Rodas, AH Metherel… - … and Essential Fatty …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFA) play essential roles in cell membrane structure and
physiological processes including signal transduction, cellular metabolism and tissue …

[HTML][HTML] Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders

M Martinat, M Rossitto, M Di Miceli, S Layé - Nutrients, 2021 - mdpi.com
n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

AH Metherel, RP Bazinet - Progress in lipid research, 2019 - Elsevier
N-3 polyunsaturated fatty acids (PUFA) and the numerous families of lipid mediators derived
from them collectively regulate numerous biological processes. The mechanisms by which n …

Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model

M Neykhonji, F Asgharzadeh, M Farazestanian… - Scientific Reports, 2024 - nature.com
Intrauterine adhesion (IUA), also referred to as Asherman's syndrome, is characterized by
fibrosis, inflammation, and can cause amenorrhea and infertility due to abnormal …

A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids

R Amarsi, S Furse, MAM Cleaton, S Maurel… - Nature …, 2024 - nature.com
The long and very long chain polyunsaturated fatty acids (LC-PUFAs) are preferentially
transported by the mother to the fetus. Failure to supply LC-PUFAs is strongly linked with …

PEMT, Δ6 desaturase, and palmitoyldocosahexaenoyl phosphatidylcholine are increased in rats during pregnancy [S]

A Chalil, AP Kitson, JJA Henao, KA Marks… - Journal of lipid …, 2018 - jlr.org
DHA is important for fetal neurodevelopment. During pregnancy, maternal plasma DHA
increases, but the mechanism is not fully understood. Using rats fed a fixed-formula diet …

High choline intake during pregnancy reduces characteristics of the metabolic syndrome in male wistar rat offspring fed a high fat but not a normal fat post-weaning …

R Hammoud, E Pannia, R Kubant, A Metherel… - Nutrients, 2021 - mdpi.com
Maternal choline intakes are below recommendations, potentially impairing the child's later-
life metabolic health. This study aims to elucidate the interaction between the choline …

Quantitative and carbon isotope ratio analysis of fatty acids isolated from human brain hemispheres

RJS Lacombe, ME Smith, K Perlman… - Journal of …, 2023 - Wiley Online Library
Our knowledge surrounding the overall fatty acid profile of the adult human brain has been
largely limited to extrapolations from brain regions in which the distribution of fatty acids …

Cod‐Liver Oil Improves Metabolic Indices and hs‐CRP Levels in Gestational Diabetes Mellitus Patients: A Double‐Blind Randomized Controlled Trial

S Yang, R Lin, L Si, Z Li, W Jian… - Journal of diabetes …, 2019 - Wiley Online Library
Objective. To investigate the effects of cod‐liver oil on metabolic status and high‐sensitivity
C‐reactive protein (hs‐CRP) in patients with gestational diabetes mellitus (GDM). Methods …

Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model

AH Metherel, RJS Lacombe, R Chouinard-Watkins… - Journal of lipid …, 2018 - jlr.org
Previous assessments of the PUFA biosynthesis pathway have focused on DHA and
arachidonic acid synthesis. Here, we determined whole-body synthesis-secretion kinetics for …