[HTML][HTML] t4 workshop report: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
N Alépée, A Bahinski, M Daneshian, B De Wever… - Altex, 2014 - ncbi.nlm.nih.gov
Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century
Microelectrode arrays (MEAs) have been in use over the past decade and a half to study
multiple aspects of electrically excitable cells. In particular, MEAs have been applied to …
multiple aspects of electrically excitable cells. In particular, MEAs have been applied to …
Rotenone exerts developmental neurotoxicity in a human brain spheroid model
Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT
and NT) and are linked to the increase in incidence of autism, attention deficit and …
and NT) and are linked to the increase in incidence of autism, attention deficit and …
Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set
ER McConnell, MA McClain, J Ross, WR LeFew… - Neurotoxicology, 2012 - Elsevier
Microelectrode array (MEA) approaches have been proposed as a tool for detecting
functional changes in electrically excitable cells, including neurons, exposed to drugs …
functional changes in electrically excitable cells, including neurons, exposed to drugs …
Biological and medical applications of a brain-on-a-chip
The desire to develop and evaluate drugs as potential countermeasures for biological and
chemical threats requires test systems that can also substitute for the clinical trials normally …
chemical threats requires test systems that can also substitute for the clinical trials normally …
In vitro bioengineered model of cortical brain tissue
A bioengineered model of 3D brain-like tissue was developed using silk-collagen protein
scaffolds seeded with primary cortical neurons. The scaffold design provides …
scaffolds seeded with primary cortical neurons. The scaffold design provides …
Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures …
Due to lack of knowledge only a few industrial chemicals have been identified as
developmental neurotoxicants. Current developmental neurotoxicity (DNT) guidelines …
developmental neurotoxicants. Current developmental neurotoxicity (DNT) guidelines …
Evidence of parallels between mercury intoxication and the brain pathology in autism
J Kern, D Geier, T Audhya, P King, L Sykes… - Acta neurobiologiae …, 2012 - ane.pl
The purpose of this review is to examine the parallels between the effects mercury
intoxication on the brain and the brain pathology found in autism spectrum disorder (ASD) …
intoxication on the brain and the brain pathology found in autism spectrum disorder (ASD) …
Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model
HT Hogberg, R de Cássia da Silveira E Sá… - Archives of …, 2021 - Springer
Due to regulatory bans and voluntary substitutions, halogenated polybrominated diphenyl
ether (PBDE) flame retardants (FR) are increasingly substituted by mainly …
ether (PBDE) flame retardants (FR) are increasingly substituted by mainly …
An IGFBP2-derived peptide promotes neuroplasticity and rescues deficits in a mouse model of Phelan-McDermid syndrome
We developed an IGFBP2-mimetic peptide fragment, JB2, and showed that it promotes
basal synaptic structural and functional plasticity in cultured neurons and mice. We …
basal synaptic structural and functional plasticity in cultured neurons and mice. We …