Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
E Maury, SM Brichard - Molecular and cellular endocrinology, 2010 - Elsevier
Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …
[PDF][PDF] Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences
The epidemic of overweight and obesity is a major problem because of the plethora of
health and economic issues that it induces. Key among these is the sharply increasing …
health and economic issues that it induces. Key among these is the sharply increasing …
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased
selectively in adipocytes. Adipose-specific knockout or overexpression of Glut4 alters …
selectively in adipocytes. Adipose-specific knockout or overexpression of Glut4 alters …
Paternal diet defines offspring chromatin state and intergenerational obesity
The global rise in obesity has revitalized a search for genetic and epigenetic factors
underlying the disease. We present a Drosophila model of paternal-diet-induced …
underlying the disease. We present a Drosophila model of paternal-diet-induced …
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
H **e, B Lim, HF Lodish - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE We investigated the regulation and involvement of microRNAs (miRNAs) in fat
cell development and obesity. RESEARCH DESIGN AND METHODS Using miRNA …
cell development and obesity. RESEARCH DESIGN AND METHODS Using miRNA …
Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression
M Jernås, J Palming, K Sjöholm, E Jennische… - The FASEB …, 2006 - Wiley Online Library
Enlarged adipocytes are associated with insulin resistance and are an independent
predictor of type 2 diabetes. To understand the molecular link between these diseases and …
predictor of type 2 diabetes. To understand the molecular link between these diseases and …
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity
DE Lackey, CJ Lynch, KC Olson… - American Journal …, 2013 - journals.physiology.org
Elevated blood branched-chain amino acids (BCAA) are often associated with insulin
resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or …
resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or …
CTRP family: linking immunity to metabolism
A Schäffler, C Buechler - Trends in Endocrinology & Metabolism, 2012 - cell.com
It is well known that infectious and inflammatory diseases such as sepsis and severe
inflammatory response syndrome are accompanied by metabolic alterations such as insulin …
inflammatory response syndrome are accompanied by metabolic alterations such as insulin …
CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity
Abstract Background/Aims: Obesity is associated with a low-grade inflammation, insulin
resistance, and macrophage infiltration of adipose tissue. The role of CC chemokines and …
resistance, and macrophage infiltration of adipose tissue. The role of CC chemokines and …
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
Transcriptional profiling of two isogenic models of transformation identifies a gene signature
linking cancer with inflammatory and metabolic diseases. In accord with this common …
linking cancer with inflammatory and metabolic diseases. In accord with this common …