Molecular mechanisms of arsenic-induced disruption of DNA repair
Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …
Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges
PD Ray, A Yosim, RC Fry - Frontiers in genetics, 2014 - frontiersin.org
Exposure to toxic metals poses a serious human health hazard based on ubiquitous
environmental presence, the extent of exposure, and the toxicity and disease states …
environmental presence, the extent of exposure, and the toxicity and disease states …
Evaluation of the carcinogenicity of inorganic arsenic
Inorganic arsenic (iAs) at high exposures is a human carcinogen, affecting mainly the
urinary bladder, lung and skin. We present an assessment of the mode of action (MOA) of …
urinary bladder, lung and skin. We present an assessment of the mode of action (MOA) of …
Epigenetic targets of some toxicologically relevant metals: a review of the literature
TF Cheng, S Choudhuri… - Journal of Applied …, 2012 - Wiley Online Library
The term epigenetics was coined in the context of developmental studies, but the meaning of
the term has evolved over time. Epigenetic modulators of gene expression are now known to …
the term has evolved over time. Epigenetic modulators of gene expression are now known to …
Targeting histone modifications—epigenetics in cancer
T Waldmann, R Schneider - Current opinion in cell biology, 2013 - Elsevier
Cancer is one of the most common human diseases. It is long known that mutations in key
regulator genes are hallmarks of all cancer types. Apart from these classical genetic …
regulator genes are hallmarks of all cancer types. Apart from these classical genetic …
Epigenetics: relevance and implications for public health
Improved understanding of the multilayer regulation of the human genome has led to a
greater appreciation of environmental, nutritional, and epigenetic risk factors for human …
greater appreciation of environmental, nutritional, and epigenetic risk factors for human …
[HTML][HTML] Arsenic and benzo [a] pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating …
Arsenic and benzo [a] pyrene (BaP) are among the most common environmental
carcinogens causing lung cancer. Millions of people are exposed to arsenic through …
carcinogens causing lung cancer. Millions of people are exposed to arsenic through …
Air pollution from polycyclic aromatic hydrocarbons generated by human activities and their health effects in China
The key factors that influence the health effects of polycyclic aromatic hydrocarbons (PAH)
air emissions generated by human activities in China were identified in this study by …
air emissions generated by human activities in China were identified in this study by …
Nutritional manipulation of one‐carbon metabolism: effects on arsenic methylation and toxicity
MN Hall, MV Gamble - Journal of toxicology, 2012 - Wiley Online Library
Exposure to arsenic (As) through drinking water is a substantial problem worldwide. The
methylation of As, a reactive metalloid, generates monomethyl‐(MMA) and dimethyl …
methylation of As, a reactive metalloid, generates monomethyl‐(MMA) and dimethyl …
Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress
Arsenic exposure is postulated to modify microRNA (miRNA) expression, leading to
changes of gene expression and toxicities, but studies relating the responses of miRNAs to …
changes of gene expression and toxicities, but studies relating the responses of miRNAs to …