Orchestrating vertebrate genomes require a complex interplay between the linear
composition of the genome and its 3D organization inside the nucleus. This requires the …

Structural maintenance of chromosomes (SMC) complexes are essential proteins found in
genomes of all cellular organisms. Essential functions of these proteins, such as mitotic …

Modern cartilaginous fishes are divided into elasmobranchs (sharks, rays and skates) and
chimaeras, and the lack of established whole-genome sequences for the former has …

Here, we report a single-cell DNA replication sequencing method, scRepli-seq, a genome-
wide methodology that measures copy number differences between replicated and …

The cerebral cortex is formed by diverse neurons generated sequentially from neural stem
cells (NSCs). A clock mechanism has been suggested to underlie the temporal progression …

Otx family homeoproteins Otx2 and Crx are expressed in photoreceptor precursor cells and
bind to the common DNA-binding consensus sequence, but these two proteins have distinct …

Developmental studies of sharks and rays (elasmobranchs) have provided much insight into
the process of morphological evolution of vertebrates. Although those studies are …

Background Hi-C is derived from chromosome conformation capture (3C) and targets
chromatin contacts on a genomic scale. This method has also been used frequently in …

Recent evidence has documented the potential roles of histone-modifying enzymes in
autism-spectrum disorder (ASD). Aberrant histone H3 lysine 9 (H3K9) dimethylation …

In many animal species with a bilateral symmetry, Hox genes are clustered either at one or
at several genomic loci. This organization has a functional relevance, as the transcriptional …