ABSTRACT Introduction: Human adenovirus (HAdV)-derived vectors have been used in
numerous pre-clinical and clinical trials during the last 40 years. Current research in HAdV …

Vaccines have been a hugely successful public health intervention, virtually eliminating
many once common diseases of childhood. However, they have had less success in …

Several effective SARS-CoV-2 vaccines are currently in use, but effective boosters are
needed to maintain or increase immunity due to waning responses and the emergence of …

Ever since the discovery of vaccines, many deadly diseases have been contained
worldwide, ultimately culminating in the eradication of smallpox and polio, which …

Mucosal immunity has regained its spotlight amidst the ongoing Coronavirus disease 19
(COVID-19) pandemic, with numerous studies highlighting the crucial role of mucosal …

Respiratory syncytial virus (RSV) infections are the leading cause of severe respiratory
illness in early infancy. Although the majority of children and adults mount immune …

Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …

Lung tissue-resident memory T cells are crucial mediators of cellular immunity against
respiratory viruses; however, their gradual decline hinders the development of T cell–based …

Gene therapies hold significant promise for treating previously incurable diseases. A
number of gene therapies have already been approved for clinical use. Currently, gene …

Successful vaccines induce specific immune responses and protect against various viral
and bacterial infections. Noninactivated vaccines, especially viral vector vaccines such as …