Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Osteoporosis is a common metabolic bone disease that results from the imbalance of
homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic …

Lysosomes are the primary degradative compartment within cells and there have been
significant advances over the past decade toward understanding how lysosome …

In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …

Autophagy is an evolutionary conserved and highly regulated recycling process of cellular
wastes. Having a housekee** role, autophagy through the digestion of domestic cytosolic …

Abstract 3D printed porous titanium alloy implants is an advanced orthopedic material for
joint replacement. However, the high risk of aseptic loosening and periprosthetic infection is …

Despite the continued development of specialized immunosuppressive therapies in the form
of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of …

Bone marrow stromal/stem cells (BMSCs) are generally considered as common progenitors
for both osteoblasts and adipocytes in the bone marrow, but show preferential differentiation …

Oxidative stress and autophagy play essential roles in the development of senile
osteoporosis which is characterized by disrupted osteoclastic bone resorption and …

As the most common bone disease, osteoporosis (OP) increases bone fragility and makes
patients more vulnerable to the threat of osteoporotic fractures. With the ageing population in …