Energy metabolism in the liver

L Rui - Comprehensive physiology, 2014 - pmc.ncbi.nlm.nih.gov
The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism

A Wahlström, SI Sayin, HU Marschall, F Bäckhed - Cell metabolism, 2016 - cell.com
The gut microbiota is considered a metabolic" organ" that not only facilitates harvesting of
nutrients and energy from the ingested food but also produces numerous metabolites that …

The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

C Yun, S Yan, B Liao, Y Ding, X Qi, M Zhao… - Nature …, 2024 - nature.com
Polycystic ovary syndrome (PCOS), an endocrine disorder afflicting 6–20% of women of
reproductive age globally, has been linked to alterations in the gut microbiome. We …

An overview of lipid metabolism and nonalcoholic fatty liver disease

K Pei, T Gui, D Kan, H Feng, Y **… - BioMed Research …, 2020 - Wiley Online Library
The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major
abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or …

Dietary supplementation of bile acid attenuate adverse effects of high-fat diet on growth performance, antioxidant ability, lipid accumulation and intestinal health in …

P Yin, S **e, Z Zhuang, X He, X Tang, L Tian, Y Liu… - Aquaculture, 2021 - Elsevier
Bile acid (BA) has been reported to improve growth performance and play an important role
in lipid metabolism of fish. Five diets were formulated to investigate the effects of dietary bile …

Intestinal bacteria interplay with bile and cholesterol metabolism: implications on host physiology

N Molinero, L Ruiz, B Sánchez, A Margolles… - Frontiers in …, 2019 - frontiersin.org
Bile is a biological fluid synthesized in the liver, mainly constituted by bile acids and
cholesterol, which functions as a biological detergent that emulsifies and solubilizes lipids …

Molecular pathways in non-alcoholic fatty liver disease

A Berlanga, E Guiu-Jurado, JA Porras… - Clinical and …, 2014 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

[HTML][HTML] Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

T Puengel, H Liu, A Guillot, F Heymann… - International journal of …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …

Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function

M Canyelles, M Tondo, L Cedó, M Farràs… - International journal of …, 2018 - mdpi.com
Recent evidence, including massive gene-expression analysis and a wide-variety of other
multi-omics approaches, demonstrates an interplay between gut microbiota and the …

FXR inhibits endoplasmic reticulum stress-induced NLRP3 inflammasome in hepatocytes and ameliorates liver injury

CY Han, HS Rho, A Kim, TH Kim, K Jang, DW Jun… - Cell reports, 2018 - cell.com
Endoplasmic reticulum (ER) stress is associated with liver injury and fibrosis, and yet the
hepatic factors that regulate ER stress-mediated inflammasome activation remain unknown …