Extracellular vesicles in cancer—implications for future improvements in cancer care
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …
cell–cell communication within complex tissue environments. Such communication …
The many functions of ESCRTs
M Vietri, M Radulovic, H Stenmark - Nature reviews Molecular cell …, 2020 - nature.com
Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …
contain cytosol. The 'classical'budding reactions, such as those occurring during …
ALIX-and ESCRT-III–dependent sorting of tetraspanins to exosomes
The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling
receptors and other proteins to lysosomes for degradation, but they also modulate …
receptors and other proteins to lysosomes for degradation, but they also modulate …
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
M Radulovic, EM Wenzel, S Gilani, LKK Holland… - The EMBO …, 2022 - embopress.org
Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are
repaired by the ESCRT machinery. Here, we describe an additional mechanism for …
repaired by the ESCRT machinery. Here, we describe an additional mechanism for …
Triggered recruitment of ESCRT machinery promotes endolysosomal repair
ML Skowyra, PH Schlesinger, TV Naismith, PI Hanson - Science, 2018 - science.org
INTRODUCTION Lysosomes are degradative organelles that break down diverse materials
delivered from inside and outside the cell by specialized vesicles called endosomes …
delivered from inside and outside the cell by specialized vesicles called endosomes …
Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery
L Christ, C Raiborg, EM Wenzel, C Campsteijn… - Trends in biochemical …, 2017 - cell.com
The endosomal sorting complex required for transport (ESCRT) machinery is an assembly of
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …
Reverse-topology membrane scission by the ESCRT proteins
The narrow membrane necks formed during viral, exosomal and intra-endosomal budding
from membranes, as well as during cytokinesis and related processes, have interiors that …
from membranes, as well as during cytokinesis and related processes, have interiors that …
ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival
M Radulovic, KO Schink, EM Wenzel, V Nähse… - The EMBO …, 2018 - embopress.org
Although lysosomes perform a number of essential cellular functions, damaged lysosomes
represent a potential hazard to the cell. Such lysosomes are therefore engulfed by …
represent a potential hazard to the cell. Such lysosomes are therefore engulfed by …
Membrane and organelle dynamics during cell division
JG Carlton, H Jones, US Eggert - Nature Reviews Molecular Cell …, 2020 - nature.com
During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …
ESCRT-mediated phagophore sealing during mitophagy
Y Zhen, H Spangenberg, MJ Munson, A Brech… - Autophagy, 2020 - Taylor & Francis
Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has
been reported to cause autophagic defects, but the exact functions of ESCRT proteins in …
been reported to cause autophagic defects, but the exact functions of ESCRT proteins in …