Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

The Lotka-Volterra (LV) model was introduced in the early 20th Century to describe predator-
prey systems. Since then, the model has been expanded to capture the dynamics of …

A First Course in Systems Biology is an introduction for advanced undergraduate and
graduate students to the growing field of systems biology. Its main focus is the development …

Background Dynamic modelling is one of the cornerstones of systems biology. Many
research efforts are currently being invested in the development and exploitation of large …

Biochemical systems are among of the oldest application areas of mathematical modeling.
Spanning a time period of over one hundred years, the repertoire of options for structuring a …

Gene regulation networks are composed of transcription factors, their interactions, and
targets. It is of great interest to reconstruct and study these regulatory networks from …

Breast cancer initiation, invasion and metastasis span multiple length and time scales.
Molecular events at short length scales lead to an initial tumorigenic population, which left …

Almost every biomedical systems analysis requires early decisions regarding the choice of
the most suitable representations to be used. De facto the most prevalent choice is a system …

Background Advances in modern high-throughput techniques of molecular biology have
enabled top-down approaches for the estimation of parameter values in metabolic systems …

Dynamic parameter estimation in cases where it may be impossible to identify all the model
parameters is considered. The objective is to obtain reliable estimates to the maximal …