The role of inflammasomes in kidney disease
T Komada, DA Muruve - Nature Reviews Nephrology, 2019 - nature.com
Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …
Generation and release of mitochondrial-derived vesicles in health, aging and disease
Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their
vital functions, mitochondrial quality control (MQC) systems are in place to support organelle …
vital functions, mitochondrial quality control (MQC) systems are in place to support organelle …
SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway
Macrophages promote an early host response to infection by releasing pro-inflammatory
cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically …
cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically …
Inflammasomes as mediators of inflammation in HIV-1 infection
AK Min, T Fortune, N Rodriguez, E Hedge… - Translational …, 2023 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) infection is a chronic disease without a known
cure. The advent of effective antiretroviral therapy (ART) has enabled people with HIV …
cure. The advent of effective antiretroviral therapy (ART) has enabled people with HIV …
Past HIV-1 medications and the current status of combined antiretroviral therapy options for HIV-1 patients
M Weichseldorfer, M Reitz, OS Latinovic - Pharmaceutics, 2021 - mdpi.com
Combined antiretroviral therapy (cART) is treatment with a combination of several
antiretroviral drugs that block multiple stages in the virus replication cycle. An estimated 60 …
antiretroviral drugs that block multiple stages in the virus replication cycle. An estimated 60 …
Human immunodeficiency virus Type‐1 single‐stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in …
Despite the availability of antiretroviral therapy (ART) that fully suppresses human
immunodeficiency virus type‐1 (HIV), markers of inflammation and minor neurocognitive …
immunodeficiency virus type‐1 (HIV), markers of inflammation and minor neurocognitive …
Role of inflammasomes in HIV-1 infection and treatment
Although combined antiretroviral therapy (cART) is effective in inhibiting human
immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because …
immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because …
Advancements in programmed cell death research in antitumor therapy: a comprehensive overview
S Wei, C Han, S Mo, H Huang, X Luo - Apoptosis, 2024 - Springer
Cell death is a normal physiological process within cells that involves multiple pathways,
such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell …
such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell …
[HTML][HTML] Oral hyperpigmentation as an adverse effect of highly active antiretroviral therapy in HIV patients: A systematic review and pooled prevalence
D Radithia, A Subarnbhesaj… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Background Human Immunodeficiency Virus (HIV) infects patients via CD4+ cells which are
later be destroyed subsequently causing the deteriotation of immune system. HIV generally …
later be destroyed subsequently causing the deteriotation of immune system. HIV generally …
Pacritinib inhibition of IRAK1 blocks aberrant TLR8 signalling by SARS-CoV-2 and HIV-1-derived RNA
Macrophages promote an early host response to infection by releasing pro-inflammatory
cytokines such as interleukin (IL) 1β (IL-1β), tumour necrosis factor (TNF), and IL-6. One of …
cytokines such as interleukin (IL) 1β (IL-1β), tumour necrosis factor (TNF), and IL-6. One of …