Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the
most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the …

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been
viewed historically as lipid storage disorders brought about by overnutrition. It is now widely …

The modern rise in obesity and its strong association with insulin resistance and type 2
diabetes have elicited interest in the underlying mechanisms of these pathologies. The …

Obesity is becoming a major health concern in Western society, and medical conditions
associated with obesity are grouped in the metabolic syndrome. Overnutrition activates …

Type 2 diabetes mellitus (T2DM) is characterized by progressive β‐cell dysfunctioning and
insulin resistance. This article reviews recent literature with special focus on inflammatory …

Redox signaling, a mode of signal transduction that involves the transfer of electrons from a
nucleophilic to electrophilic molecule, has emerged as an essential regulator of …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Purpose of Review. Describing the diverse molecular mechanisms (particularly
immunological) involved in the death of the pancreatic beta cell in type 1 and type 2 …

Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the
pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance …