Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Type 2 diabetes mellitus (T2DM) increases the risk of many lethal and debilitating
conditions. Among them, foot ulceration due to neuropathy, vascular disease, or trauma …

Proteomic approaches have unique advantages in the identification of biological pathways
that influence physical frailty, a multifactorial geriatric syndrome predictive of adverse health …

The immune system is integral to cardiovascular health and disease. Targeting inflammation
ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of …

Background Adipose tissue remodeling plays a significant role in obesity-induced insulin
resistance. Published studies reported that level of trigger receptor expressed on myeloid …

Objective To investigate the association between serum soluble triggering receptor
expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor …

Abstract Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) is a membrane protein
expressed on immune cells, involved in neurodegenerative diseases and cancer. Recently …

Despite the advancement in the treatment, nonhealing diabetic foot ulcers (DFUs) are an
important clinical issue accounting for increased morbidity and risk of amputation. Persistent …

Inflammation mediated by myeloid cells trigger receptors 1 (TREM-1) is important for
atherosclerosis development, while sirtuin 6 (Sirt6) levels decrease in atheroscleoritc …

Osteoarthritis (OA) is a degenerative disease characterized by the destruction of cartilage.
The greatest risk factors for the development of OA include age and obesity. Recent studies …