The biological and clinical significance of emerging SARS-CoV-2 variants
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …
spike protein mutations that are influencing the epidemiological and clinical aspects of the …
Viral targets for vaccines against COVID-19
L Dai, GF Gao - Nature Reviews Immunology, 2021 - nature.com
Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19)
pandemic and to help the return to pre-pandemic normalcy. A great many vaccine …
pandemic and to help the return to pre-pandemic normalcy. A great many vaccine …
[HTML][HTML] Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …
SARS‐CoV‐2 Omicron variant: characteristics and prevention
X He, W Hong, X Pan, G Lu, X Wei - MedComm, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) has brought about a great threat to global
public health. Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS …
public health. Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS …
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …
The humoral response and antibodies against SARS-CoV-2 infection
Two and a half years into the COVID-19 pandemic, we have gained many insights into the
human antibody response to the causative SARS-CoV-2 virus. In this Review, we …
human antibody response to the causative SARS-CoV-2 virus. In this Review, we …
Monoclonal antibody therapies against SARS-CoV-2
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …
Antibody-mediated neutralization of SARS-CoV-2
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
Immunity to SARS‐CoV‐2 induced by infection or vaccination
Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …