Compounds containing 1, 3, 4-oxadiazole ring in their structure are characterised by
multidirectional biological activity. Their anti-proliferative effects associated with various …

Thiazolidinedione (TZD) containing derivatives have been proved to be promising
anticancer agents in preclinical and clinical evaluation phases. Hybrid molecules not just …

Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …

Abstract Indole based thiadiazole derivatives (1–18) were synthesized and evaluated for
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …

Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely
explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1 …

New benzimidazole derivatives were synthesized by reacting substituted phenacyl bromides
with 1 H-benzimidazole-2-thiols. The synthesized compounds were characterized through 1 …

In continuation of our work on enzyme inhibition, the benzofuran-based-thiazoldinone
analogues (1–14) were synthesized, characterized by HREI-MS, 1H and 13CNMR and …

Thymidine phosphorylase (TP) is over expressed in several solid tumors and its inhibition
can offer unique target suitable for drug discovery in cancer. A series of 1, 2, 4-triazoles 3a …

Triazinoindole bearing bis-Schiff base analogs (1–20) were synthesized by triazinoindole-
thione ring formation, triazinoindole-thiol-phenylethanone, followed by triazinoindole bis …

The reaction of 5-(3, 4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2 (3 H)-thione 3 with
formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol …