Migraine is a complex disorder of the brain whose mechanisms are only now being
unraveled. It is common, disabling and economically costly. The pain suggests an important …

Migraine is a common and disabling brain disorder with a strong inherited component.
Because patients with migraine have severe and disabling attacks usually of headache with …

Background: Medically intractable chronic migraine (CM) is a disabling illness characterized
by headache≥ 15 days per month. Methods: A multicenter, randomized, blinded, controlled …

Headache is the most common problem for which patients seek care from a neurologist, and
primary headaches, such as migraine and cluster headache, are the most common …

Migraine is a largely inherited disorder of the brain characterized by a complex, but
stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is …

Background Hemicrania continua (HC) is a primary headache that comprises persistent
unilateral pain, is associated with cranial autonomic features, and is responsive to …

Headache disorders are common problems in medicine and it is this commonness that often
provides an air of the simple or obvious. Patients expect doctors understand headache; …

The terms refractory headache and intractable headache have been used interchangeably
to describe persistent headache that is difficult to treat or fails to respond to standard and/or …

Occipital nerve stimulation (ONS) may be effective for the treatment of headaches that are
recalcitrant to medical therapy. The objective of this study was to determine if response to …

Neurostimulation therapy involves the use of peripheral or central nerve electrical
stimulation approaches for the treatment of medically intractable headache. Currently, for …