Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases

P Chaudhary, P Janmeda, AO Docea… - Frontiers in …, 2023 - frontiersin.org
Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

SA Bonini, M Premoli, S Tambaro, A Kumar… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Cannabis sativa L.(C. sativa) is an annual dioecious plant,
which shares its origins with the inception of the first agricultural human societies in Asia …

Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens

NA Mahizan, SK Yang, CL Moo, AAL Song, CM Chong… - Molecules, 2019 - mdpi.com
The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive
research to find alternative therapeutics. Plants rich with natural secondary metabolites are …

β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats

Q Hu, T Zuo, L Deng, S Chen, W Yu, S Liu, JD Liu… - Phytomedicine, 2022 - Elsevier
Background Ischemic stroke is a complex brain disease regulated by several cell death
processes, including apoptosis, autophagy, and ferroptosis. β-Caryophyllene (BCP), a …

Fibromyalgia: recent advances in diagnosis, classification, pharmacotherapy and alternative remedies

ME Maffei - International journal of molecular sciences, 2020 - mdpi.com
Fibromyalgia (FM) is a syndrome that does not present a well-defined underlying organic
disease. FM is a condition which has been associated with diseases such as infections …

Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis

AM Tomko, EG Whynot, LD Ellis, DJ Dupré - Cancers, 2020 - mdpi.com
In recent years, and even more since its legalization in several jurisdictions, cannabis and
the endocannabinoid system have received an increasing amount of interest related to their …

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

OC Ugbogu, O Emmanuel, GO Agi, C Ibe, CN Ekweogu… - Heliyon, 2021 - cell.com
In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various
diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and …

Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus

T Nuutinen - European journal of medicinal chemistry, 2018 - Elsevier
Cannabaceae plants Cannabis sativa L. and Humulus lupulus L. are rich in terpenes–both
are typically comprised of terpenes as up to 3–5% of the dry-mass of the female …

Cannabis pharmacology: the usual suspects and a few promising leads

EB Russo, J Marcu - Advances in pharmacology, 2017 - Elsevier
The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and
his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and …

β-Caryophyllene: a sesquiterpene with countless biological properties

F Francomano, A Caruso, A Barbarossa, A Fazio… - Applied sciences, 2019 - mdpi.com
β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid
agonist of type 2 receptors (CB2-R). It isn't psychogenic due to the absence of an affinity to …